Medication Sequencing Guideline for Management of Drug Carryover

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Purpose: Some feed manufacturing facilities use medications (drugs) in the production of feed products. This document describes the policy the Canadian Food Inspection Agency (CFIA) will use to determine if these facilities have developed and are using the necessary procedures and controls intended to mitigate the risks associated with the use of medications in their facility, such as the carryover of medications between feed batches.

Applicability and Scope: Facilities manufacturing or handling livestock feeds, and medicating ingredients or medicated feeds.

Regulatory Requirements

In Canada, the use of drugs in livestock feeds is regulated under two sets of legislation: the Food and Drugs Act and Regulations, which are administered by Health Canada's Veterinary Drugs Directorate, and the Feeds Act and Regulations, which are administered by the CFIA. Livestock is defined as cattle, sheep, horses, chickens, turkeys, geese, ducks, swine, rabbits, fish, mink and foxes.

The Compendium of Medicated Ingredient Brochures (CMIB) is a listing of drug premixes that have been approved and assigned a Drug Identification Number (DIN) by Health Canada. These premixes can be used without veterinary oversight in livestock feeds, as long as they are used in accordance with the CMIB (e.g., for the approved species, at the approved level).

Desired Outcome

Control and management of medication residues in feeds that are not intended to contain them contributes to safe feed, prudent use of medications, as well as food safety. This includes controls to ensure the appropriate dosage of the correct medications in medicated livestock feeds and to control cross-contamination with medicated feeds with other feeds.

Cross-contamination of feeds occurs when substances, including medications which according to the formulation are not intentionally included in the feed, have been carried over from previous use of the same equipment. This carryover can be minimized through the use of effective equipment and good manufacturing practices, but cannot be completely eliminated without physical cleaning of the equipment.

If carryover is not properly managed, cross-contamination with medicated feeds can:

  • harm species that are sensitive to the drug residues they consume,
  • contribute to antimicrobial resistance, and
  • lead to drug residues in food products.

The CFIA recognizes that the prevention of comingling or cross-contamination of feeds with medications through the use of dedicated equipment, or equipment cleanout, is not always practical. The Agency also considers the risk associated with unintentional medication residues acceptable in cases where there is no negative impact on animal or human health.

Considering these factors, the CFIA has developed guidelines to permit the production of medicated and non-medicated feeds in cross-utilized equipment, where feeds containing medications are followed only by feeds intended to contain those same medications, or by feeds where residual levels of the carryover medications present an acceptable risk. The CFIA's assessment of acceptable production sequences involving medications considers whether the medication residue(s) are appropriate for the species and class of animal affected.

Medication Sequencing Guideline for Management of Drug Carryover

The Medication Sequencing Guideline for Management of Drug Carryover is used by CFIA inspection staff to assess the acceptability of feed production sequences involving medications. The guideline considers whether the medication residue(s) is (are) appropriate for the species and class of animal feed affected. It provides a listing of each approved drug, and identifies the types of feed (by species and class of animals) in which it is acceptable to have residual levels of that drug.

With a few exceptions, the information in the guideline reflects the intended uses detailed in the CMIB. The most notable set of exceptions are the result of a joint project between the CFIA and Health Canada designed to quantify the risks associated with carryover of individual drug residues, and to identify flexibilities or restrictions for production sequences where appropriate.

In cases where the order of feed production through common equipment occurs in an acceptable sequence, specific cleanout of the equipment is not required. In cases where the feed cannot be manufactured in an acceptable production order, the equipment involved must be cleaned (by flushing or other physical cleanout) using validated procedures. Information regarding acceptable procedures for validating equipment cleanout is available in Acceptable Validation Testing Procedures for Equipment Clean-out Procedures.

Associated documents

The following documents are used in association with the Medicated Sequencing Guideline for Management of Drug Carryover:

Medication Sequencing Guideline for Management of Drug Carryover

For use by CFIA inspection staff as a guide in assessing the adequacy of written clean out procedures for cross-utilized equipment used to manufacture and handle medicated feeds containing different medications or medicated and non-medicated feeds in commercial feed mills, feed retail outlets and on-farm feed mills.

For the most part, these guidelines reflect the intended uses detailed in the Compendium of Medicating Ingredient Brochures (CMIB) which are based on the submissions from the drug companies to Health Canada for approval, with the following exceptions:

  1. Concerns related to residues of Sulfamethazine in barbecue hogs has limited sequencing as a viable drug management strategy in commercial feed mills and feed retail outlets for this medication to swine starter rations (swine <20kg) with labelled withdrawal times of at least 7 days. For on-farm situations, greater sequencing flexibility remains as the livestock producer will have access to information on the feeding practices for the animals on the farm and be able to determine whether a residue might be present in animals receiving feeds that contain residual levels of Sulfamethazine.
  2. Health Canada and the CFIA are conducting a joint Drug Carryover Risk Project to evaluate the risks associated with carryover drug residues for both approved and unapproved uses in order to provide additional guidance on management strategies supporting the development of production sequences that will result in the manufacture of feeds that do not negatively impact on either animal or human health. This version of the Medication Sequencing Guideline includes the results of evaluations to date, e.g., where scientifically justified, carryover levels of medications such as Chlortetracycline Hydrochloride, Lasalocid Sodium, and Lincomycin are now considered acceptable in certain additional species or production classes of animal for which the drug is not approved in the CMIB. Updates to the Medication Sequencing Guideline will continue to be made as the evaluation of additional drugs is completed.
  3. In the absence of safety evaluations, Emergency Drugs Release (EDRs) can only be sequenced when both feeds contain the same (EDR).

Remarks

  1. This guide requires that inspection staff consider concentration of medications in feeds when assessing sequencing procedures to verify that carryover does not result in the feeds (unintentionally) containing treatment levels of medications (for example, a complete feed might safely follow a medicated complete feed but it may not be safe for that same complete feed to follow a medicated premix or other medicated feed containing high concentrations of the same drug).
  2. Market Ready is defined as follows:
    1. For feeds manufactured in commercial feed mills - feeds labelled for consumption by finishing animals, growing swine, laying hens and lactating animals producing milk intended for human consumption or where the labelling does not specify the stage of production (e.g. swine ration).
    2. For feeds manufactured on-farm feeds intended for feeding to animals that produce food for human consumption (meat, milk, eggs) within the withdrawal period for the drug being fed. Special caution needs to be used when culling sows or selecting BBQ hogs, etc. to make sure that animals that have consumed a feed containing a medication that has a withdrawal period are fed non-medicated feed for a period equal to the withdrawal period for that medication prior to being shipped.
Medication Sequencing Guideline for Management of Drug Carryover
Medication Brand Name MIB # Approved For Withdrawal May Follow With Feeds For
Amprolium
  • AMPROL FEED PREMIX
27 Turkeys (up to 16 weeks of age)
Replacement chickens (not laying birds in production)
Broiler chickens (not laying birds in production)
Calves (not replacement)
7 days for calves Turkeys up to 16 weeks of age
Chickens up to 18 weeks
Calves (not replacement) (not market ready)
AvilamycinTable Note 4
  • SURMAX 100 PREMIX
    (DIN # 02421062)
  • SURMAX 200 PREMIX (DIN# 02436760)
Dec. 2015 2015 Broiler Chickens Swine (less than 14 weeks of age) none Broiler Chickens Swine (less than 14 weeks of age)
Bacitracin Methylene Disalicylate
  • BMD 110 G MEDICATED PREMIX
  • BACITRACIN MD PREMIX
10.2 Chickens (starter, grower, finisher)
Turkeys (starter, grower, finisher)
Swine (starter, grower, finisher)
none

Chickens up to 14 weeks

Turkeys - meat birds up to market weight
Swine

  • BMD 110 G MEDICATED PREMIX
  • BACITRACIN MD PREMIX
48 Broiler Chickens
Pregnant and Lactating Sows and Gilts
none Chickens up to 14 weeks

Turkeys - meat birds up to market weight
Swine

Bacitracin Zinc
  • ALBAC 110 ZINC BACITRACIN PREMIX
10.2 Chicken (starter, grower, finisher)
Turkeys (starter, grower, finisher)
Swine (starter, grower, finisher)
none Chickens up to 14 weeks
Turkeys – meat birds up to market weight
Swine
  • ALBAC 110 ZINC BACITRACIN PREMIX
37A Chickens
Swine
none Chickens up to 14 weeks
Turkeys – meat birds up to market weight
Swine
Bambermycins
  • FLAVOMYCIN 4 ANTIBIOTIC PREMIX
10.12 Broiler Chickens up to market weight (not laying, replacement or breeders)
Broiler Turkeys up to 12 weeks (not replacement or breeding)
none Chickens – Meat birds up to market weight
Turkeys - Meat birds up to 12 weeks
Chlortetracycline Hydrochloride
  • AUREOMYCIN 50
  • AUREOMYCIN 220G GRANULAR MEDICATED PREMIX
  • AUREOMYCIN 110G MEDICATED PREMIX
10.1
Sept. 2010
Chickens (0-12 weeks of age)
Turkeys (0-24 weeks of age)
Swine (starter, grower, finisher)
Calves (starter and grower)
Lambs (starter, grower, finisher)
Mink
none Chickens
Turkeys
Swine
Cattle (not lactating dairy cattle producing milk for food)
Lambs
Mink
  • AUREOMYCIN 50
  • CHLOROSOL 50 PREMIX
  • AUREOMYCIN 220G GRANULAR MEDICATED PREMIX
  • AUREOMYCIN 110G MEDICATED PREMIX
34
∆ May 2012
Broiler Chickens
Laying Chickens
Replacement Chickens (up to 14 weeks)
Turkeys
Turkey Pullets (up to 5 days)
Feed-lot Lambs
Swine
Beef
Non-Lactating Dairy Cattle
Calves up to 136 kg/milk replacers

4 days
Lambs

5 days
Beef Cattle
Non lactating Dairy Cattle,
Calves

7 days
Chickens
Turkeys
Swine

Chickens (not market ready - meat)
Turkeys (not market ready)
Lambs (not market ready)
Swine (not market ready)
Calves up to 136 kg (not market ready)
Beef Cattle (not market ready)
Non-Lactating Dairy Cattle (not market ready)
  • AUREOMYCIN 220G GRANULAR MEDICATED PREMIX
  • AUREOMYCIN 110G MEDICATED PREMIX
34
∆ May 2012
Swine (Claim 43)

4 days
Lambs

5 days
Beef Cattle
Non lactating Dairy Cattle,
Calves

7 days
Chickens
Turkeys
Swine

Chickens (not market ready - meat)
Turkeys (not market ready)
Lambs (not market ready)
Swine (not market ready)
Calves up to 136 kg (not market ready)
Beef Cattle (not market ready)
Non-Lactating Dairy Cattle (not market ready)
  • CHLOR 50
  • CHLOR 100
  • DERACIN 22% GRANULAR PREMIX
34
∆ May 2012
Swine (Claims 35, 36, 37, 38, 39)
Calves up to 136 kg/milk replacers (Claims 41, 42)
Beef Cattle (Claim 40) (not for slaughter)
Non-Lactating Dairy Cattle (Claim 40) (not for slaughter)

4 days
Lambs

5 days
Beef Cattle
Non lactating Dairy Cattle,
Calves

7 days
Chickens
Turkeys
Swine

Chickens (not market ready - meat)
Turkeys (not market ready)
Lambs (not market ready)
Swine (not market ready)
Calves up to 136 kg(not market ready)
Beef Cattle (not market ready)
Non-Lactating Dairy Cattle (not market ready)
Chlortetracycline Hydrochloride and Sulfamethazine
  • AUREO S-700 G PREMIX
  • CHLOR S-700
49
Dec. 2015
Beef Cattle (for first 4 weeks after entering feedlot) 10 days Beef Cattle (first 4 weeks after entering the feedlot; not market ready)
Swine ((Starter swine (<20 kg) feeds with a minimum 7 day withdrawal or on-farm feed mills only, not market ready)
Chickens – meatTable Note 1 (on-farm feed mills only, not breeding, not market ready)
Turkeys – meatTable Note 1 (on-farm feed mills only, not breeding, not market ready)
Chlortetracycline Hydrochloride, Sulfamethazine, and Procaine Penicillin
  • AUREO S-P 250 G PREMIX
  • AUREOMIX 625 G PREMIX
  • CHLOR 250
  • SUPER CHLOR 250
  • CHLOROSOL 250 PREMIX
  • SUPER CHLOROSOL 250 PREMIX
38
Dec. 2015
Swine 10 days Swine (Starter swine (<20 kg) feeds with a minimum 7 day withdrawal or on-farm feed mills only, not market ready)
Chickens – meatTable Note 1 (on-farm feed mills only, not breeding, not market ready)
Turkeys – meatTable Note 1 (on-farm feed mills only, not breeding, not market ready)
Clopidol
  • COYDEN 25 ANTICOCCIDIAL PREMIX
45 Broiler Chickens (not laying hens)
Replacement Chickens up to 16 weeks of age (not birds intended for breeding purposes)
None Chickens up to 16 weeks
Decoquinate
  • DECCOX 6% PREMIX
50 Broiler Chickens (not laying birds)
Cattle (not lactating dairy cattle producing milk for food)
None

Chicken - meat birds up to market weight

Cattle (not lactating dairy cattle producing milk for food)

  • DECCOX-M PREMIX
50 In milk replacers for non-ruminating calves, including veal calves None

Chicken - meat birds up to market weight

Cattle (not lactating dairy cattle producing milk for food)

Diclazuril
  • CLINACOX 0.5% PREMIX
77 Broiler Chickens up to slaughter
Growing Turkeys (up to 14 weeks in age)
none Chickens - meat birds up to market weight. Growing Turkeys (up to 14 weeks in age).
Erythromycin Thiocyanate
  • GALLIMYCIN 50 PREMIX
41
∆ May 2012
Breeding Chickens (not chickens producing eggs for food) 24 hours As a result of the Drug Carryover Risk Project, sequencing with any feed that is not intended to contain erythromycin thiocyanate is not considered a viable drug management strategy.
Fenbendazole
  • SAFE-GUARD PREMIX 20%
72 Swine
Cattle
13 days cattle Swine
Cattle (not market ready)
Halofuginone Hydrobromide
  • STENOROL PREMIX
76 Broiler Chickens (not laying, replacement or breeders) 5 days Chickens - meat birds raised for slaughter (not market ready)
Ivermectin
  • IVOMEC PREMIX FOR SWINE
  • IVOMEC 0.04% PREMIX FOR SWINE
  • ULTRAMECTRIN PREMIX FOR SWINE
  • NOROMECTIN PREMIX FOR SWINE
78 Swine

5 days

14 days for breeding swine (IVOMEC Premix only)

Swine (not market ready)
Lasalocid Sodium
  • AVATEC 20 LASALOCID SODIUM PREMIX
  • BOVATEC 20 LASALOCID SODIUM PREMIX
66
Jan. 2013
Broiler Chickens, Turkeys, Cattle (non-lactating) and Lambs 2 days Lambs Chickens - meat birds up to market weight
Turkeys - meat birds up to market weight
SheepTable Note 1
CattleTable Note 1
SwineTable Note 1
Lincomycin
  • LINCOMIX 44 PREMIX
  • LINCOMIX 110 PREMIX
  • LINCOMYCIN 44 PREMIX
  • LINCOMYCIN 110 PREMIX
  • LINCOMYCIN 44 G PREMIX
  • LINCOMYCIN 110 G PREMIX
68
Jan. 2012
Swine (not breeding swine) None - 1 day SwineTable Note 1 (not breeding swine)
ChickensTable Note 2 - meat birds up to market weight
TurkeysTable Note 1 (not breeding turkeys)
Lincomycin and Spectinomycin
  • L-S 20 PREMIX
  • LINCOMYCIN-SPECTINOMYCIN 4.4% G PREMIX
62
Jan. 2012
Swine up to 57 kg intended for slaughter 24 hours SwineTable Note 1 (not breeding swine, not market ready)
Maduramicin Ammonium
  • CYGRO 1% PREMIX
71 Broiler Chickens (not laying, replacements or breeders)
Turkeys (not laying, replacement or breeders)
5 days Chickens - meat birds raised for slaughter (not market ready)
Turkeys - meat birds raised for slaughter (not market ready)
Melengestrol Acetate
  • MGA 100 PREMIX
46 Beef Cattle (heifers only, 181 kg or more) 24 hours Beef Cattle - heifers only, 181 kg or more (not market ready)
Monensin Sodium
  • COBAN PREMIX
  • RUMENSIN PREMIX
  • MONENSIN PREMIX
57
Feb. 2012
Broiler Chickens (not replacement or laying chickens)
Turkeys up to 10 weeks of age (not replacement, laying or breeding turkeys)
Beef Cattle
Cattle
Pasture Cattle
none Chickens - meat birds up to market weight
Turkeys raised for slaughter up to market weight
CattleTable Note 1
SwineTable Note 1
Lambs, Ewes and RamsTable Note 1
  • COBAN PREMIX
  • RUMENSIN PREMIX
57
Feb. 2012
Lactating Dairy Cows
Dry and Lactating Dairy Cows
none Chickens - meat birds up to market weight
Turkeys raised for slaughter up to market weight
CattleTable Note 1
SwineTable Note 1
Lambs, Ewes and RamsTable Note 1
Morantel Tartrate
  • BANMINTH II 20% PREMIX
61 Cattle
Swine
30 days Cattle (not market ready)
Swine (not market ready)
Narasin
  • MONTEBAN 70 PREMIX
  • MONTEBAN 100 PREMIX
73
Jan. 2013
Broiler Chickens (not laying birds)
Growing-Finishing Swine (20 kg to market weight, not replacement)
none Chickens - meat birds up to market weight
Beef CattleTable Note 1
SwineTable Note 1
Narasin and Nicarbazin
  • MAXIBAN PREMIX
75
Jun. 2014
Broiler Chickens (not laying birds or breeding hens in production) none Chickens - meat birds raised for slaughter
Nicarbazin
  • NICARB 25% PREMIX
9
Jun. 2014
Chickens (not laying or breeder hens in production) 4 days Chickens up to 18 weeks of age
TurkeysTable Note 1 - meat birds
Nitarsone
  • HISTOSTAT 50
81 Turkeys (not laying, replacement or breeding) 5 days Turkeys - meat birds not market ready
Oxytetracycline Hydrochloride
  • TERRAMYCIN-AQUA
35A Salmonids (salmon and trout) 40-80 days Salmonids (salmon & trout) (not market ready)
  • TERRAMYCIN-50
  • TERRAMYCIN-100
  • TERRAMYCIN-200
  • OXYSOL 220
  • OXYSOL 440
  • OXYTETRACYCLINE 50 PREMIX
  • OXYTETRACYCLINE 100 PREMIX
  • OXYTETRACYCLINE 200 PREMIX
  • OXY – 110
  • OXY – 220
  • OXY – 440
35
∆ May 2012
Broiler Chickens (not laying hens, Claim 8 - 220mg/kg)
Laying Chickens
Replacement Chickens (not laying hens, Claim 21 - 220 mg/kg)
Turkeys
Lambs
Swine
Young cattle on pasture or in feedlots (Not dairy cows)
Calves/ Calf milk replacers
4 days
Lambs
5 days
Calves
7 days
all others

Chickens (not market ready - meat)

Turkeys (not market ready)

Lambs (not market ready)

Swine (not market ready)

Cattle not including Lactating Dairy Cows (not market ready)

Oxytetracycline Hydrochloride and Neomycin Sulphate
  • NEO-TERRAMYCIN 50/50 PREMIX
55 Beef Cattle 7 days Beef Cattle (not market ready)
Penicillin from Procaine Penicillin
  • PEN-P 110
  • PEN-P 1000
  • PENICILLIN G PROCAINE 110
  • PROMED 110
  • PROMED 1000
10.7
Feb. 2012
Chickens up to 14 weeks (starter, grower and finisher) none ChickensTable Note 1 – (not breeding, not laying)
SwineTable Note 3 (OK as per previous versions of MIB 37)
TurkeysTable Note 3 - (not breeding)
Piperazine
  • PIPERAZINE 52
  • ASCAREX D
19 Turkeys
Chickens
Swine
none Turkeys
Chickens
Swine
Poloxalene
  • BLOAT-GUARD
56 Cattle none Cattle
Pyrantel Tartrate
  • PRO-BANMINTH PREMIX
64 Swine intended for slaughter 7 days Swine intended for slaughter (not market ready)
Ractopamine Hydrochloride
  • PAYLEAN 20 PREMIX
  • ENGAIN 20
82
∆ Aug 2014
Finishing Barrows and Gilts ≥ 70 kg (not breeding or replacement swine)
Finishing heavy Turkeys, toms and hens
(not breeding)
none

Finishing Swine ≥ 70 kg (not breeding or replacement swine)
Finishing heavy toms or hens Turkeys for the last 14 days prior to slaughter (not breeding)

Cattle (steers and heifers) (greater than 400 kg fed in confinement 28-42 days prior to slaughter) (not lactating dairy cattle and calves to be processed for veal)

  • OPTAFLEXX 100 PREMIX
  • ACTOGAIN 100
82
∆ Aug 2014
Cattle greater than 400 kg (steers and heifers) fed in confinement 28-42 days prior to slaughter (not lactating dairy cattle and calves to be processed for veal) none

Finishing Swine ≥7 0 kg (not breeding or replacement swine)
Finishing heavy toms or hens Turkeys for the last 14 days prior to slaughter (not breeding)

Cattle (steers and heifers) (greater than 400 kg fed in confinement 28-42 days prior to slaughter) (not lactating dairy cattle and calves to be processed for veal)

Robenidine Hydrochloride
  • ROBENZ MEDICATED PREMIX
58

Broiler Chickens (not laying, replacement and breeders)

Broiler Turkeys (under 8 weeks of age) (not replacement and breeders)

Weaned and growing Rabbits (not breeding rabbits or pregnant does)

6 days

Chickens - meat birds raised for slaughter (not market ready)

Turkeys - meat birds raised for slaughter under 8 weeks of age

Weaned and growing Rabbits - not breeding rabbits or pregnant does (not market ready)

Salinomycin Sodium
  • POSISTAC 6% PREMIX
  • COXISTAC 6% PREMIX
10.13
∆ June 2015

Swine (growing-finishing, 25kg body weight to market weight) (not breeding swine)

Weaned and growing rabbits – not male or female rabbits intended for reproduction including pregnant does and does in lactation

none

5 days

SwineTable Note 1 (not breeding swine)

Weaned and growing rabbits – not male or female rabbits intended for reproduction including pregnant does and does in lactation (not market ready)

Chickens - meat birds up to market weight  

Beef Cattle steers greater than 220 kgs
Beef Cattle heifers greater than 220 kgs(not replacement or breeding heifers)

  • COXISTAC 6% PREMIX
  • COXISTAC 12% PREMIX
  • POSISTAC 6% PREMIX
  • SACOX 120 MEDICATED PREMIX
  • SALINOMYCIN 60 PREMIX
  • BIO-COX 120 G PLUS PREMIX
69
∆ June 2015

Broiler Chickens (not replacement, laying, or breeding chickens)

Beef Cattle (steers and feedlot heifers greater than 220 kg) (not replacement or breeding cattle)

None

24 hours for Heifers

SwineTable Note 1 (not breeding swine)

Weaned and growing rabbits – not male or female rabbits intended for reproduction including pregnant does and does in lactation (not market ready)

Chickens - meat birds up to market weight

Beef Cattle steers greater than 220 kgs
Beef Cattle heifers greater than 220 kgs(not replacement or breeding heifers)

Semduramicin Sodium
  • AVIAX MEDICATED PREMIX 5%
79 Broiler Chickens (not laying, breeders or replacemen chickens) 2 days Chickens - meat birds raised for slaughter (not market ready)
Tiamulin
  • DENAGARD MEDICATED PREMIX
  • TIAMULIN 1.78% PREMIX
  • DENAGARD 10% GF PREMIX
  • TAMULIN HF 10% PREMIX
74 Swine (not for gilts and sows during four weeks after service) 2 – 7 days Swine (not market ready or gilts/sows within four weeks after service)
Tilmicosin
  • PULMOTIL PREMIX
  • TILMOVET PREMIX
80
Dec. 2011

Swine (Tilmovet Premix only)
(excluding boars used for breeding)

Feedlot Beef Cattle
(not pre-ruminant calves or replacement or breeding cattle)

14 days swine

28 days beef

Swine (not market ready) (excluding boars used for breeding)

Feedlot Beef Cattle (not market ready) (not pre-ruminant calves or replacement or breeding cattle)

Tylosin Phosphate
  • TYLAN 10 PREMIX
  • TYLAN 40 PREMIX
  • TYLAN 100 PREMIX
  • TYLOSIN 40 PREMIX
10.10 Swine (starter, grower, finisher) none

Swine
Beef Cattle (not replacement, breeding or lactating cattle)
Chickens - meat birds up to market weight

  • TYLAN 10 PREMIX
  • TYLAN 40 PREMIX
  • TYLAN 100 PREMIX
  • TYLOSIN 10 PREMIX
  • TYLOSIN 40 PREMIX
  • PHARMASIN 100 PREMIX
43 Swine
Beef Cattle (not replacement, breeding or lactating Cattle)
Broiler Chickens (not laying hens)
48 hours for Swine treated concurrently with this drug in the complete feed and with tylosin tartrate in drinking water Swine
Beef Cattle (not replacement, breeding or lactating cattle)
Chickens - meat birds up to market weight
Tylosin Phosphate and Sulfamethazine
  • TYLAN 50/SULFA G PREMIX
67 Swine starter feeds 10 days Starter swine (<20 kg) feeds (with a minimum 7 day withdrawal or on-farm feed mills only, not market ready)
Tylvalosin Tartate
  • AIVLOSIN 17% PREMIX
84 Swine (not male or female swine intended for reproduction including pregnant swine and swine in lactation) None Swine (not male or female swine intended for reproduction including pregnant swine and swine in lactation)
Virginiamycin
  • STAFAC 22
  • STAFAC 44
  • STAFAC 500
  • VIRGINIAMYCIN 44 PREMIX
10.11

Swine (starter, grower, finisher)

Broiler Chickens (starter, grower, finisher; not laying, replacement or breeding chickens)

none Swine
Chickens - meat birds up to market weight
  • STAFAC 22
  • STAFAC 44
  • STAFAC 500
  • VIRGINIAMYCIN 44 PREMIX
63 Swine
Broiler Chickens (not laying, replacement or breeding chickens)
none Swine
Chickens - meat birds up to market weight
Zilpaterol Hydrochloride
  • ZILMAX PREMIX
83 For Beef Cattle greater than 450 kg body weight fed in confinement for slaughter (not calves to be processed for veal) (not animals intended for breeding) 4 days Beef Cattle greater than 450kg (on-farm only, not market ready) (not calves to be processed for veal or animals intended for breeding)
Zinc Bacitracin and Procaine Penicillin
  • BACIFERM-PB-50
37
Feb. 2012
Chickens (not laying or breeding chickens)
Swine
none

ChickensTable Note 1 (not breeding, not laying)
Swine

TurkeysTable Note 1 - (not breeding)

Zoalene
  • ZOAMIX MEDICATED PREMIX
7 Broiler Chickens (not laying hens)
Replacement Chickens up to 14 weeks of age
Turkeys up to 7 weeks of age
none Chickens up to 14 weeks of age
Turkeys up to 7 weeks of age

Table Notes

Table Note 1

Additional flexibility as a result of the Drug Carryover Risk Project

Return to table note 1 referrer

Table Note 2

As MIB 10.5 was removed from the CMIB for reasons not related to animal health or food safety, the previously accepted sequences are still considered valid

Return to table note 2 referrer

Table Note 3

As MIB 10.14 was removed from the CMIB for reasons not related to animal health or food safety, the previously accepted sequences are still considered valid

Return to table note 3 referrer

Table Note 4

Prescription only drug

Return to table note 4 referrer

Date modified: