Tylosin Phosphate - MIB #43

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Date Revised: 2010-02

Approved Brands

1. TYLAN 10 PREMIX contains tylosin (as tylosin phosphate) at 22 g/kg (Elanco).
2. TYLAN 40 PREMIX contains tylosin (as tylosin phosphate) at 88 g/kg (Elanco).
3. TYLAN 100 PREMIX contains tylosin (as tylosin phosphate) at 220 g/kg (Elanco).
4. TYLOSIN 10 PREMIX contains tylosin (as tylosin phosphate) at 22 g/kg (Bio Agri Mix Limited).
5. TYLOSIN 40 PREMIX contains tylosin (as tylosin phosphate) at 88 g/kg (Bio Agri Mix Limited).

Approved for use

In meal or pellet feed for swine, broiler chickens and beef cattle.

Note: TYLOSIN 10 PREMIX and TYLOSIN 40 PREMIX are approved only for Claims 1, 2, 3 and 4.

Approved claims

For swine - Claim 1, 2, 3, 5, 7, 8
For beef cattle - Claim 4
For broiler chickens - Claim 6

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Note:

Positive diagnosis by a veterinarian is essential before using tylosin phosphate for the treatment and prevention of swine dysentery or porcine proliferative enteropathy or for the treatment of necrotic enteritis broiler chickens.

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Claim 1: As an aid in treatment of Swine Dysentery

Level of Drug:

110 mg/kg (0.011%) of complete feed.

Direction:

Feed this medicated feed as the sole ration for three weeks. Tylosin tartrate medicated drinking water should be provided for the first three days of treatment or until symptoms disappear.

Note:

1. Treatment following positive diagnosis involves placing the swine on water medication consisting of one gram of tylosin tartrate per 3.785 litres of drinking water. This should be given for three days or until symptoms disappear.
2. Concurrent with drinking water therapy, a tylosin phosphate medicated swine feed is to be fed as the sole ration.
3. After concurrent therapy of the drinking water and the feed, as set above in program steps 1 and 2, a prophylactic swine feed is to be fed.

Warning:

1. Swine treated concurrently with this drug in the complete feed and with tylosin tartrate in drinking water must not be slaughtered for use in food for at least 48 hours after the latest treatment with tylosin in drinking water.

Caution:

1. Do not use in feeds containing pellet binding agents with the exception of Lignosol (4%) and Agri-Colloid (0.3%).(Premix and supplement labels only).
2. Do not use in feeds containing bentonite. (Premix and supplement labels only).
3. When treating swine dysentery, the diagnosis should be redetermined in cases of lack of response within 3 to 5 days of treatment commencement.

Claim 2: As an aid in prevention of cyclic recurrence following treatment of Swine Dysentery

Level of Drug:

44 mg/kg (0.0044%) of complete feed.

Direction:

Feed this medicated feed as the sole ration until hogs reach market weight.

Note:

Swine Dysentery appears sporadically in swine herds in Canada.

Caution:

1. Do not use in feeds containing pellet binding agents with the exception of Lignosol (4%) and Agri-Colloid (0.3%). (Premix and supplement labels only).
2. Do not use in feeds containing bentonite. (Premix and supplement labels only).

Claim 3: As an aid in the prevention of Porcine Proliferative Enteropathy (ileitis), associated with Lawsonia intracellularis

Level of Drug:

110 mg/kg (0.011%) of complete feed.

Direction:

Feed this medicated feed as the sole ration for 21 days, commencing prior to an anticipated outbreak of disease.

Caution:

1. Do not use in feeds containing pellet binding agents with the exception of Lignosol (4%) and Agri-Colloid (0.3%). (Premix and supplement labels only).
2. Do not use feeds containing bentonite. (Premix and supplement labels only).

Claim 4: To reduce the incidence of Liver Abscesses caused by Actinomyces pyogenes and Fusobacterium necrophorum in beef cattle (steers and heifers) fed in confinement for slaughter.

Level of Drug:

11 mg/kg (0.0011%) of complete diet including roughage (100% Dry Matter Basis).

Direction:

Feed continuously as the sole ration.

Note:

Tylan 10 and Tylan 40 Premix only can be used in the following thixotrope liquid supplements:

1. HCS, Nutrena Feeds, Cargill Limited.
2. Promolas Liquid Supplement Suspension, Westway Feed Products.

Caution:

1. Do not feed to replacement, breeding or lactating cattle.
2. Do not use in feeds containing pellet binding agents with the exception of Lignosol (4%) and Agri-Colloid (0.3%). (Premix and supplement labels only).
3. Do not use in feeds containing bentonite. (Premix and supplement labels only).
4. Do not use thixotropic supplements after four weeks storage (Cargill thixotropic liquid supplement labels only).
5. Do not use thixotropic supplements after eight weeks storage (Promolas Liquid Supplement Suspension Westway Feed Products, thixotropic liquid supplement labels only).

Claim 5: As an aid in the treatment of porcine proliferative enteropathy (ileitis), associated with Lawsonia intracellularis when used following treatment with Elanco Tylan Soluble.

Level of Drug:

110 mg/kg (0.011%) of complete feed.

Direction:

Feed this medicated feed as the sole ration for 7 days following treatment with Elanco Tylan Soluble.

Note:

1. Treatment following positive diagnosis involves placing the swine on water medication consisting of one gram of Elanco Tylan Soluble per 12 litres of drinking water (83 mg per litre) for 7 days followed by Elanco Tylan Premix in feed at a rate of 110 mg/kg of complete feed for 7 days.

Warning:

1. Swine treated concurrently with this drug in the complete feed with Elanco Tylan Soluble in drinking water must not be slaughtered for use in food for at least 48 hours after the latest treatment with tylosin in drinking water.

Caution:

1. Do not use in feeds containing pellet binding agents with the exception of Lignosol (4%) and Agri-Colloid (0.3%). (Premix and supplement labels only).
2. Do not use in feeds containing bentonite. (Premix and supplement labels only).

Claim 6: As an aid in the treatment of necrotic enteritis caused by Clostridium perfringens in broiler chickens

Level of Drug:

200 mg/kg (0.020%) of complete feed.

Direction:

Feed this medicated feed as the sole ration for 7 days.

Warning:

1. Do not use in laying hens.
2. Do not use for growth promotion in poultry.

Caution:

1. Do not use in feeds containing pellet binding agents with the exception of Lignosol (4%) and Agri-Colloid (0.3%). (Premix and supplement labels only).
2. Do not use in feeds containing bentonite. (Premix and supplement labels only).
3. When treating necrotic enteritis, the diagnosis should be redetermined in cases of lack of response within 3 to 5 days of treatment commencement.

Claim 7: For the treatment of porcine proliferative enteropathy or ileitis, associated with Lawsonia intracellularis

Level of Drug:

110 mg/kg (0.011%) of complete feed.

Direction:

Feed this medicated feed as the sole ration for 3 weeks.

Caution:

1. Do not use in feeds containing pellet binding agents with the exception of Lignosol (4%) and Agri-Colloid (0.3%). (Premix and supplement labels only).
2. Do not use in feeds containing bentonite. (Premix and supplement labels only).
3. When treating Porcine Proliferative Enteropathy the diagnosis should be confirmed by a veterinarian when results are not satisfactory.

Claim 8: For the treatment of porcine proliferative enteropathy or ileitis, associated with Lawsonia intracellularis in the presence of persistent or recurring infection.

Level of Drug:

1. 110 mg/kg (0.011%) of complete feed for 3 weeks.
2. 44 mg/kg (0.0044%) of complete feed for the following 3 weeks.

Direction:

1. Feed 110 mg/kg (0.011%) medicated feed as the sole ration for 3 weeks. This MUST be followed by 44 mg/kg medicated feed for the next 3 weeks.
2. Feed 44 mg/kg (0.0044%) medicated feed as the sole ration for 3 weeks ONLY after having fed 110 mg/kg medicated feed for 3 weeks.

Caution:

1. Do not use in feeds containing pellet binding agents with the exception of Lignosol (4%) and Agri-Colloid (0.3%). (Premix and supplement labels only).
2. Do not use in feeds containing bentonite. (Premix and supplement labels only).
3. When treating Porcine Proliferative Enteropathy the diagnosis should be confirmed by a veterinarian when results are not satisfactory.

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Accepted Compatibilities

Tylosin phosphate is compatible with the following drug/drug combinations. For details, refer to the MIB as indicated.

Number	Medicated ingredients	For use in feed for
1.	Arsanilic acid (MIB #4)	swine
2.	Monensin sodium (MIB #57) at 11 mg/kg or 33 mg/kg in complete diets including roughage (100% dry matter basis)	beef cattle