Zilpaterol Hydrochloride - MIB #83

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Date Revised: 2009-06

Approved Brands

1. ZILMAX PREMIX contains zilpaterol hydrochloride at 48 g/kg (Intervet Canada Corp.).

Approved for use

In meal and pellet feed for finishing beef cattle.

Approved claims

For beef cattle greater than 450 kg body weight fed in confinement for slaughter -
Claim 1.

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Claim 1: For increased carcass leanness, increased dressing percent, improved rate of body weight gain and improved feed efficiency in beef cattle fed in confinement for slaughter during the last 20 - 40 days on feed

Level of Drug:

8.3 mg/kg (0.008%) of the total diet.

Note:

Total diet refers to the complete feed plus the roughage and must be corrected to a 100% dry matter basis.

Level of drug in supplements*, premixes and grain rations to be mixed with forages:

At levels so that when used as directed, supplies the average intake as specified below.

Weight of Cattle (kg)	Zilpaterol Hydrochloride Dosage (mg/head/day)
450	63.50
500	74.70
550	86.74
600	99.60

Directions:

Feed continuously as sole ration to finishing beef cattle greater that 450 kg body weight for the last 20 to 40 days on feed. Supplements, premixes and grain rations must be thoroughly mixed in the total diet before use. Do not feed undiluted.

*Note:

Zilmax Premix can be used in liquid supplements under the following conditions:

• liquid supplements should be in a pH range of 3.8 - 7.5
• liquid supplements should be agitated daily, and prior to use, for 10 - 20 minutes
• liquid supplements may contain zilpaterol hydrochloride at a level of 83 - 830 g/tonne.

Warning:

1. Treated animals must not be slaughtered for use in food for at least four (4) days after the latest treatment with this medicated feed.
2. Do not feed to calves to be processed for veal.
3. Zilpaterol hydrochloride is a beta₂-adrenergic agonist. Individuals with cardiovascular disease should exercise special caution to avoid exposure to this medicated feed (Required on Premix and Supplement labels only).
4. When mixing and handling this medicated feed, use protective clothing, impervious gloves, and a dust mask. Operators should wash thoroughly with soap and water after handling. If accidental eye contact occurs, immediately rinse thoroughly with water. If irritation persists, seek medical attention (Required on Premix and Supplement labels only).
5. Keep out of reach of children (Required on Premix and Supplement labels only).

Caution:

1. Do not feed to animals intended for breeding.
2. Do not allow horses or other equines access to this medicated feed.
3. Animals receiving zilpaterol hydrochloride may exhibit an increased respiratory rate as well as elevated levels of creatine phosphokinase (CPK) and creatinine.
4. Recirculate or agitate daily, and prior to use, for 10 - 20 minutes (liquid supplement labels only).

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Accepted Compatibilities

Nil