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Tilmicosin (TIL) - Medicating Ingredient Brochure

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Status: Veterinary prescription required for approved claims

Revised July 2021

Table of approved species and claims
Approved livestock species Approved claim(s)
(abbreviated) Table Note 1
Withdrawal time Name of approved brand(s)
Swine
  1. Aid in reducing the severity of swine respiratory disease (SRD)
  2. Aid in reducing the severity of porcine polyserositis and arthritis
14 days
(meat)
  1. Pulmotil Premix
  2. Tilmovet Premix
  3. Tilmicosin 200 Premix
Feedlot beef cattle
  1. Reduction of bovine respiratory disease (BRD) morbidity
28 days
(meat)
  1. Pulmotil Premix
  2. Tilmovet Premix
  3. Tilmicosin 200 Premix
Rabbits
  1. Reduction in severity of respiratory disease
4 days
(meat)
  1. Pulmotil Premix
  2. Tilmicosin 200 Premix

Table Notes

Table Note 1

In order to be compliant with the Feeds Regulations, the complete claim must appear on the medicated feed label.

Return to table note 1  referrer

Swine

Table of approved claims and brands
Approved claims Name of approved brand(s) Drug concentration in DIN product
Claims
1, 2
  1. Pulmotil Premix
  2. Tilmovet Premix
  3. Tilmicosin 200 Premix
Tilmicosin (as tilmicosin phosphate) at 200 g/kg

Claim 1

As an aid in reducing the severity of swine respiratory disease (SRD) associated with Actinobacillus pleuropneumoniae and Pasteurella multocida when fed to pigs approximately 7 days prior to an anticipated disease outbreak.

Level of medicating ingredient in the complete feed

200 mg/kg (0.02%) of tilmicosin in the complete feed

Directions for use in the complete feed

This livestock feed contains a medically important antibiotic. To reduce the development of antimicrobial resistance and maintain effectiveness, use this antibiotic prudently and for the shortest duration required to achieve the desired clinical outcome.

The medicated feed is to be fed continuously as the sole ration for a 21-day period beginning approximately 7 days before an anticipated disease outbreak.

Additional information (not to appear on feed labels)

For feed manufacturers

Add and thoroughly mix into the ration at the following rate to provide 200 mg/kg (0.02%) tilmicosin per metric tonne (1000 kg) of finished (complete) feed:

Warning

  1. Treated animals must not be slaughtered for use in food for at least 14 days after the latest treatment with this medicated feed when fed at the recommended level of 200 mg/kg (0.02%) tilmicosin in the complete feed.
  2. To limit the development of antimicrobial resistance, tilmicosin should only be used in swine at high risk of developing swine respiratory disease (SRD) or Glasser's Disease.
  3. When mixing and handling this product, avoid inhalation, oral exposure, and direct contact with skin or eyes. Use protective clothing, impervious gloves, and a dust mask. Operators should wash thoroughly with soap and water after handling. If accidental eye contact occurs, immediately rinse thoroughly with water. If irritation persists, seek medical attention. (Required on premix and supplement labels only).
  4. Keep out of reach of children. (Required on premix and supplement labels only).

Caution

  1. Do not use in animals hypersensitive to tilmicosin.
  2. Tilmicosin is known to be toxic for horses. Do not allow horses or other equines access to feeds containing tilmicosin.
  3. The safety of tilmicosin has not been established in boars used for breeding.
  4. Do not use in any feed containing bentonite. Bentonite in feeds may affect the efficacy of tilmicosin. (Required on premix and supplement labels only)

Additional information to be added as a note to feed labels

Note

  1. To promote responsible use and limit the development of antimicrobial resistance, use only when factors associated with outbreaks of SRD or Glasser's Disease (such as herd health status, target pig population, herd management and environmental factors, etc.) have been carefully considered.

Claim 2

As an aid in reducing the severity of porcine polyserositis and arthritis associated with Haemophilus parasuis (Glasser's Disease) when fed to pigs approximately 7 days prior to an anticipated disease outbreak.

Level of medicating ingredient in the complete feed

400 mg/kg (0.04%) of tilmicosin in the complete feed

Directions for use in the complete feed

This livestock feed contains a medically important antibiotic. To reduce the development of antimicrobial resistance and maintain effectiveness, use this antibiotic prudently and for the shortest duration required to achieve the desired clinical outcome.

The medicated feed is to be fed continuously as the sole ration for a 21-day period beginning approximately 7 days before an anticipated disease outbreak.

Additional information (not to appear on feed labels)

For feed manufacturers

Add and thoroughly mix into the ration at the following rate to provide 400 mg/kg (0.04%) tilmicosin per metric tonne (1000 kg) of finished (complete) feed:

Warning

  1. Treated animals must not be slaughtered for use in food for at least 14 days after the latest treatment with this medicated feed when fed at the recommended level of 400 mg/kg (0.04%) tilmicosin in the complete feed.
  2. To limit the development of antimicrobial resistance, tilmicosin should only be used in swine at high risk of developing swine respiratory disease (SRD) or Glasser's Disease.
  3. When mixing and handling this product, avoid inhalation, oral exposure, and direct contact with skin or eyes. Use protective clothing, impervious gloves, and a dust mask. Operators should wash thoroughly with soap and water after handling. If accidental eye contact occurs, immediately rinse thoroughly with water. If irritation persists, seek medical attention. (Required on premix and supplement labels only)
  4. Keep out of reach of children. (Required on premix and supplement labels only)

Caution

  1. Do not use in animals hypersensitive to tilmicosin.
  2. Tilmicosin is known to be toxic for horses. Do not allow horses or other equines access to feeds containing tilmicosin.
  3. The safety of tilmicosin has not been established in boars used for breeding.
  4. Do not use in any feed containing bentonite. Bentonite in feeds may affect the efficacy of tilmicosin. (Required for premix and supplement labels only).

Additional information to be added as a note to feed labels

Note

  1. To promote responsible use and limit the development of antimicrobial resistance, use only when factors associated with outbreaks of SRD or Glasser's Disease (such as herd health status, target pig population, herd management and environmental factors, etc.) have been carefully considered.

Accepted Compatibilities

Nil

Feedlot beef cattle

Table of approved claims and brands
Approved claims Name of approved brand(s) Drug concentration in DIN product
Claim 1
  1. Pulmotil Premix
  2. Tilmovet Premix
  3. Tilmicosin 200 Premix
Tilmicosin (as tilmicosin phosphate) at 200 g/kg

Claim 1

For the reduction of bovine respiratory disease (BRD) morbidity associated with Mannheimia haemolytica, Pasteurella multocida and/or Histophilus somni in groups of feedlot beef cattle experiencing an outbreak of BRD.

Level of medicating ingredient in the complete feed

At a level in supplements, premixes and complete feeds that, when used as directed, supplies 12.5 mg of tilmicosin/ per kg of body weight in the daily total diet, on a per head per day basis.

Directions for use in the complete feed

This livestock feed contains a medically important antibiotic. To reduce the development of antimicrobial resistance and maintain effectiveness, use this antibiotic prudently and for the shortest duration required to achieve the desired clinical outcome.

Feed continuously as a sole ration to feedlot beef cattle for a 14-day period in the total diet (total mixed ration).

Feed labels will be required to state the body weight(s) of the beef cattle being fed.

Additional information (not to appear on feed labels)

For feed manufacturers

Tilmicosin drug premixes should be blended into an intermediate mix (premix or supplement) and then mixed into the complete diet [total mixed ration (TMR)] to supply 12.5 mg tilmicosin 64 per kg of body weight (BW). The following is the calculation to determine the concentration of tilmicosin in the complete feed and the intermediate mix.

  1. Calculate the amount (mg) of tilmicosin activity required per head per day
    • body weight (kg) × 12.5 mg/kg BW
  2. Calculate the dry matter intake (DMI) in kg per head per day
    • body weight (kg) × estimated DMI as a percent of BW
  3. Calculate the concentration (mg/kg) in the complete diet (TMR)
    • amount (mg) of tilmicosin required per head per day divided by the DMI (kg)
  4. Calculate the concentration of tilmicosin in the intermediate mix (mg/kg = g/tonne).
    • concentration in the complete diet (mg/kg) divided by the intended inclusion rate (%) of the intermediate mix in the complete diet
  5. Calculate the amount of tilmicosin premix (kg) to be added per tonne (1000 kg) of the intermediate mix
    • concentration of tilmicosin (g/tonne) in the intermediate mix divided by the concentration (200 g tilmicosin per kg)

For example:

Body weight is 300 kg; dry matter intake as a percent of body weight is 2%; intermediate premix or supplement is to be incorporated in the complete feed at a rate of 4% of dry matter.

  1. 300 kg × 12.5 mg/kg = 3750 mg tilmicosin per head per day
  2. 300 kg × 2% (or 300 × 0.02) = 6 kg dry matter intake per head per day
  3. 3750 mg tilmicosin per head per day divided by 6 kg DMI = 625 mg tilmicosin/kg DMI
  4. 625 mg/kg divided by 4% inclusion (or 625 mg/kg divided by 0.04) = 15,625 mg/kg = 15,625 g/tonne tilmicosin in the intermediate mix
  5. 15,625 g/tonne tilmicosin in the intermediate mix divided by 200 g tilmicosin per kg tilmicosin premix = 78.125 kg/tonne

Warning

  1. Treated animals must not be slaughtered for use in food for at least 28 days after the latest treatment with this medicated feed when fed at the recommended rate of 12.5 mg tilmicosin per kg of body weight per day.
  2. Do not use in lactating dairy cattle.
  3. When mixing and handling this product, avoid inhalation, oral exposure, and direct contact with skin or eyes. Use protective clothing, impervious gloves, and a dust mask. Operators should wash thoroughly with soap and water after handling. If accidental eye contact occurs, immediately rinse thoroughly with water. If irritation persists, seek medical attention. (Required on premix and supplement labels only)
  4. Keep out of reach of children. (Required on premix and supplement labels only)

Caution

  1. Do not use in animals hypersensitive to tilmicosin.
  2. Tilmicosin is known to be toxic for horses. Do not allow horses or other equines access to feeds containing tilmicosin.
  3. The effects of tilmicosin on bovine reproductive performance, pregnancy and lactation have not been determined.
  4. The safety of tilmicosin in pre-ruminant calves has not been established.
  5. Do not use in any feed containing bentonite. Bentonite in feeds may affect the efficacy of tilmicosin. (Required on premix and supplement labels only)

Additional information to be added as a note to feed labels

Note

To promote responsible use and limit the development of antimicrobial resistance, use only under the following conditions:

Accepted Compatibilities

Tilmicosin is compatible with the following drug/drug combinations. In cases where there are differences in withdrawal time for the compatible medicating ingredients, the longer withdrawal time is the one that must be used, and is the only one that is to appear on the label of the finished feed. For details, refer to the MIB as indicated.

Tilmicosin (feedlot beef cattle)
Name of medicating ingredient MIB code Name of approved brand(s) Applicable claims
Monensin MOS
  1. Coban Premix
  2. Rumensin Premix
  3. Monensin Premix
  4. Monovet Monensin Premix
Claim 1
(beef cattle)

Rabbits

Table of approved claims and brands
Approved claims Name of approved brand(s) Drug concentration in DIN product
Claim 1
  1. Pulmotil Premix
  2. Tilmicosin 200 Premix
Tilmicosin (as tilmicosin phosphate) at 200 g/kg

Claim 1

For the reduction in severity of respiratory disease caused by Pasteurella multocida in rabbits.

Level of medicating ingredient in the complete feed

At a level in supplements and premixes that, when used as directed, supplies 12.5 mg of tilmicosin per kg of body weight in the total diet, which is equivalent to 200 mg/kg (0.02%) of tilmicosin in the complete feed.

Directions for use in the complete feed

This livestock feed contains a medically important antibiotic. To reduce the development of antimicrobial resistance and maintain effectiveness, use this antibiotic prudently and for the shortest duration required to achieve the desired clinical outcome.

Feed continuously as a sole ration to rabbits for a 7-day period in the total daily ration.

Additional information (not to appear on feed labels)

For feed manufacturers

Warning

  1. Treated animals must not be slaughtered for use in food for at least 4 days after the latest treatment with this medicated feed when fed at the recommended rate of 12.5 mg tilmicosin per kg of body weight per day.
  2. When mixing and handling this product, avoid inhalation, oral exposure, and direct contact with skin or eyes. Use protective clothing, impervious gloves, and a dust mask. Operators should wash thoroughly with soap and water after handling. If accidental eye contact occurs, immediately rinse thoroughly with water. If irritation persists, seek medical attention. (Required on premix and supplement labels only)
  3. Keep out of reach of children. (Required on premix and supplement labels only)

Caution

  1. Do not use in animals hypersensitive to tilmicosin.
  2. Tilmicosin is known to be toxic for horses. Do not allow horses or other equines access to feeds containing tilmicosin.
  3. The effects of tilmicosin on rabbit reproductive performance, pregnancy and lactation have not been determined.
  4. Do not use in any feed containing bentonite. Bentonite in feeds may affect the efficacy of tilmicosin. (Required on premix and supplement labels only)

Accepted Compatibilities

Nil

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